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Oseltamivir is an antiviral neuraminidase inhibitor with potent and selective competitive inhibition of the influenza virus neuraminidase, an enzyme necessary for viral replication. Oseltamivir phosphate is an inactive prodrug that exerts pharmacologic activity when hydrolyzed in vivo to the active form, oseltamivir carboxylate.
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The results obtained from these trials have either been promising, negative, or conflicting. Oseltamivir is an antiviral drug used for treating influenza A and B viruses . As an ester prodrug oseltamivir is converted to an active intermediate oseltamivir carboxylase, which then acts as an inhibitor of influenza neuraminidase .
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Oseltamivir is used in the treatment of the infection caused by the flu virus (influenza A and influenza B). Oseltamivir may also be used to prevent and treat swine influenza A. Oseltamivir may reduce flu symptoms (weakness, headache, fever, cough, runny or stuffy nose, and sore throat) by 1 day. Oseltamivir is also used to prevent influenza.
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2 weeks to less than 1 year: 3 mg/kg orally twice a day. 1 to 12 years: Weight up to 15 kg: 30 mg orally twice a day. Weight 15.1 to 23 kg: 45 mg orally twice a day. Weight 23.1 to 40 kg: 60 mg orally twice a day. Weight at least 40.1 kg: 75 mg orally twice a day. 13 years or older: 75 mg orally twice a day.
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Oseltamivir is an antiviral medication that blocks the actions of influenza virus types A and B in your body. Oseltamivir is used to treat influenza in people 2 weeks of age and older who have had flu symptoms for 2 days or less. Oseltamivir may also be given to prevent influenza in people who may have been exposed but do not yet have symptoms.
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Oseltamivir is used for influenza virus A and B infections. Follow the dosing instructions carefully and remember to complete the course. You can help prevent the virus from spreading to others by using clean tissues to cover your mouth and nose when you cough or sneeze, and by washing your hands regularly.
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Oseltamivir is a neuraminidase inhibitor; however, SARS-CoV S2 lacks the surface neuraminidase protein, which led to controversy regarding its use in COVID-19. In vitro and ex vivo studies suggest that oseltamivir may act differently in COVID-19 by dampening neutrophil activation and increasing its survival in a mouse model of severe sepsis-.
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oseltamivir + influenza nasal vaccine, live vaccinate at least 2wk before or 48h after oseltamivir tx; if oseltamivir tx given less than 2wk after vaccine, revaccinate w/ non-live influenza vaccine : combo may result in inadequate vaccine response (antiviral effect may inactivate vaccine)
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Methods. This is a single-center retrospective cohort study of 285 confirmed Covid-19 in patients at (XXX). Depending on the date of admission, the patients were divided into two groups; group 1 (oseltamivir group) from February 20, 2020 to March 15, 2020 received Oseltamivir with routine regimen and group 2 (control group) from March 20, 2020 to April 20, 2020 received routine regimen alone.
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Redness, blistering, peeling, or loosening of the skin, including inside the mouth. Seizures. Tremors or shaking. Trouble speaking. Unusual changes in behavior. Side effects that usually do not require medical attention (report to your care team if they continue or are bothersome): Headache.
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Oseltamivir is in a class of medications called neuraminidase inhibitors. It works by stopping the spread of the flu virus in the body. Oseltamivir helps shorten the time that flu symptoms such as a stuffy or runny nose, sore throat, cough, muscle or joint aches, tiredness, headache, fever, and chills last.
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For treatment of the flu: Adults and teenagers—75 milligrams (mg) or 12.5 milliliters (mL) two times a day (one in the morning and one in the evening) for 5 days. Children 1 year of age and older—Dose is based on body weight and must be determined by your doctor. It is usually between 30 to 75 mg or 5 to 12.5 mL two times a day for 5 days.
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Oseltamivir is used to treat symptoms caused by the flu virus ().It helps make the symptoms (such as stuffy nose, cough, sore throat, fever/chills, aches, tiredness) less severe and shortens the.
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Generic Name Oseltamivir DrugBank Accession Number DB00198 Background. Oseltamivir (marketed as the product TamifluⓇ), is an antiviral neuraminidase inhibitor used for the treatment and prophylaxis of infection with influenza viruses A (including pandemic H1N1) and B. Oseltamivir exerts its antiviral activity by inhibiting the activity of the viral neuraminidase enzyme found on the surface.
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Oseltamivir is appropriate for treating acute, uncomplicated influenza A or B illness in adults and pediatric patients, including neonates greater than two weeks of age. Neonates under two weeks of age may also receive oseltamivir to treat influenza, but safety and efficacy in this population have not been established. Nevertheless, multiple national advisory bodies have endorsed using.